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Create a new virtual disk and move mailboxes off the original store to new store.<br />
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Also its considered bad practice to degrag VMs.
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Create a new virtual disk and move mailboxes off the original store to new store.

Also its considered bad practice to degrag VMs.

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I have a Windows 2003 64bit VM running Exchange 2007. On the VM I have two volumes, C: and G:. The C drive includes the OS and Exchange App, the G: drive has all of the mailbox stores. I need to defragment the C: drive. I analyzed the C: drive and it reports 80% fragmented and Im starting to run out of disk space. <br />
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Should I have any concerns running a standard defragment on the C: drive. I know there are quite a few issues when defraging a mailbox store but I will not be touching that volume.
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I have a Windows 2003 64bit VM running Exchange 2007. On the VM I have two volumes, C: and G:. The C drive includes the OS and Exchange App, the G: drive has all of the mailbox stores. I need to defragment the C: drive. I analyzed the C: drive and it reports 80% fragmented and Im starting to run out of disk space. 

Should I have any concerns running a standard defragment on the C: drive. I know there are quite a few issues when defraging a mailbox store but I will not be touching that volume.

Defrag Windows 2003 64bit with Exchange 2007

Windows Server 2003 was based on Windows XP and was released in four editions: Web, Standard, Enterprise and Datacenter. It also had derivative versions for clusters, storage and Microsoft’s Small Business Server. Important upgrades included integrating Internet Information Services (IIS), improvements to Active Directory (AD) and Group Policy (GP), and the migration to Automated System Recovery (ASR).

Windows Server 2003

Exchange is the server side of a collaborative application product that is part of the Microsoft Server infrastructure. Exchange's major features include email, calendaring, contacts and tasks, support for mobile and web-based access to information, and support for data storage.

Exchange

Virtualization is the act of creating a virtual (rather than actual) version of something, including (but not limited to) a virtual computer hardware platform, operating system (OS), storage device, or computer network resources. Virtualization is usually the creation of a system that executes separate from the underlying hardware resources, or the creation of an entire desktop for systems located elsewhere, similar to thin clients.