How to resolve file access issues when sending a pdf attachment to a document managemt system?

I have five users connecting to a terminal server. There is a common task they need to preform on a daily basis and that is to send pdf attachment's to a document management system.
Two out of the five users cannot send pdf attachments and they get an error:
The file U:\sharedpath\xxxxxxx.pdf cannot be moved. Please ensure it exists and is not currently in use.
The users run windows 7 desktop computers, logon to the company domain (SBS2011) and click on their rdp icon to logon to the terminal server.
I have compared user accounts under AD, checked permissions on scan folder, checked user group membership for all five users and cannot see any difference.
Users can send word documents but not pdf documents.
I have tried using various combinations of logins to narrow down the problem.
I believe I have  established that the windows account, document management account and the rdp icon properties are not the issue.
The problem occurs when two specific user accounts are used to establish the terminal server connection (when the users click on the rdp icon and logon with their accounts).
Is there a way to reset or recreate the two terminal server user profiles?
Is it possible to copy a working user profile, rename it and customise it or do I need to delete the two accounts and create from scratch?
Any other suggestions?
stevenvelIT ConsultantAsked:
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Mohammed KhawajaManager - Infrastructure:  Information TechnologyCommented:
Go to Computer Properties, Advanced, user profiles and deleted one of the users profile who is experiencing the issue.  Upon next logon, profile will be recreated.
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stevenvelIT ConsultantAuthor Commented:
Recreating the user profile did the trick.
Many thanks!
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Windows Server 2008

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