Is it possible to update a DataTable existing rows?

I'm using a DataTable to handle detail records. The flow of logic is that a user retrieves a 1 Header Record and 1 or more Detail Records from the Database. The Detail Records are loaded into a DataGridView. Each time the user selects a Detail Record from the DGV, it loads the data into various controls on the Windows Form. What I would like to do is simply assign each DataColumn to each control and then just Update or Refresh the DataRow and then the DataTable. I'm pretty sure this can be done but not exactly sure how to execute it.

Thanks!