Exchange 2013 and intermittently losing connectivity

This is an Exchange 2013 CU2 install.  It's once year old and pretty static.  

Over the last few weeks, more and more users are reporting that their outlook is showing a popup that outlook is trying to retrieve information from the exchange server.  This lasts about 30-45 seconds.

It's a VM and my host and VM both have substantial resources.  There is more than sufficient HD space and RAM and my NIC throughput is low.  It's a gigabit NIC and it seldom breaks over 10MBps.  The log is clean, as in nothing even close to reporting a problem, but still, I have actually been onsite and seen the popup and experienced it myself.  

Again, this is random, intermittent, sporadic and only lasts about 30-45 seconds.

I'm thinking I'll do CU6 tonight, but I'm looking for other ideas as well.

Any thoughts on what could be causing the problem?

BTW- I can resolve fine and my DNS is good.

Thanks

Cliff
crp0499CEOAsked:
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Simon Butler (Sembee)ConsultantCommented:
CU5 or 6 would be the first thing I would do. You need to keep up to date.
Also ensure any AV on the server has the correct exclusions in place.

Simon.
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crp0499CEOAuthor Commented:
Hoping you would answer.  My thoughts too.  I did the original install and it's been flawless up until now.  Only one reboot the whole year.  Will knock out CU6 tonight and monitor.
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Simon Butler (Sembee)ConsultantCommented:
One reboot in a year? Are you not patching Windows then? Most servers I look after have about 45 days between reboots.

You need to keep Exchange 2013 up to date. Not only because it is still being actively developed, but also as Microsoft only support the current and previous CU. CU2 is very old so issues with the installation aren't really valid unless seen on a later version.

Simon.
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crp0499CEOAuthor Commented:
I am quite selective about what I patch.  Up time is important to me and if something is working, I tend not to "fix" it.  If I have a specific problem and there is a patch to fix that problem, I'll run it.  Otherwise, I let sleeping dogs lie.
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Simon Butler (Sembee)ConsultantCommented:
The "aint broke, don't fix it" attitude no longer applies in todays security environment.
When Microsoft release updates the bad guys will reverse engineer them and then attempt to attack the flaws they fix. There have also been a number of "zero day" flaws patched recently. Leave it a week or two, but you need to keep up to date, otherwise you will become a target. I tell clients when it comes to patching that there will always be someone else who hasn't patched and will be a softer target, you don't want to be that soft target.

Simon.
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crp0499CEOAuthor Commented:
I like the last sentence...softer target.  It's a conversation I have often.  I keep things pretty tight and try and keep abreast of what's happening.  When MS releases a patch, I usually read them, research them and decide then if I want to run it.  So far, that philosophy has worked well for me.  Like now, it didn't take me long to research, eliminate everything that it isn't and then arrive at the need for CU6.
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crp0499CEOAuthor Commented:
CU6 fixed her right up!
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