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But the question: <br />
<br />
Lets say I have 10 people on domain1.com<br />
30 people on domain2.com<br />
<br />
The 30 people are not users, but I just want to manage their email for domain2. Do they need to be on AD?
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But the question:

Lets say I have 10 people on domain1.com
30 people on domain2.com

The 30 people are not users, but I just want to manage their email for domain2. Do they need to be on AD?

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Can Exchange host multiple domains Email on SBS 2008? If so do I need to setup each user on Active Directory?
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Can Exchange host multiple domains Email on SBS 2008? If so do I need to setup each user on Active Directory?

Exchange

Exchange is the server side of a collaborative application product that is part of the Microsoft Server infrastructure. Exchange's major features include email, calendaring, contacts and tasks, support for mobile and web-based access to information, and support for data storage.

Small Business Server (SBS) is a line of server operating systems targeted at small businesses by bundling the operating system with a number of other Microsoft products that would normally need to be purchased or licensed separately. The most notable inclusions are Exchange, SQL Server, SharePoint and ISA/TMG (Microsoft's firewall and proxy server).

Active Directory (AD) is a Microsoft brand for identity-related capabilities. In the on-premises world, Windows Server AD provides a set of identity capabilities and services, and is hugely popular (88% of Fortune 1000 and 95% of enterprises use AD). This topic includes all things Active Directory including DNS, Group Policy, DFS, troubleshooting, ADFS, and all other topics under the Microsoft AD and identity umbrella.