Select iphones under able to connect to Exchange 2007

The weirdest thing is happening with our exchange, two weeks ago select users using iPhones cant connect to our exchange server using the email app on the iphone.  Maybe 5 out of 200 users, and from what I've seen it's only on newer accounts. If you take that same user and use a 3rd part app like cloud magic, the user account works.

The only error we are getting is below:
Unable to send a notification for subscription GgB0cnMtZXhjaGFuZ2UucmlnaHRzdGVwLmNvbRAAAADdOyUwyza4Rb+f8gbks2PA. (Send attempts: 6)

The only change we've made was 3 weeks ago, remove a PDC, transferred roles and demoted the server. First thoughts are that is the cause of this, but everything is checking out.

Any idea?
TRSTeamAsked:
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Simon Butler (Sembee)ConsultantCommented:
First thing to check is that the users who this is affecting have inherited permissions enabled. The error is permission related.
Also ensure the server is fully up to date.

Simon.
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