Site Build Help: SEO, Design, and Mobile

I am starting a new site from scratch and want to use this as an opportunity to expand my archaic skills to a more conventional level.  Lets start with this:
1) What is a good foundation for the site?  HTML5?
2) What is a good design environment to use that will create a site that renders well on multiple platforms.

Any direction would be much appreciated.
Bob SchneiderCo-OwnerAsked:
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Bob SchneiderCo-OwnerAuthor Commented:
Is this a good place to start?  http://www.google.com/think/multiscreen/
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Jason C. LevineNo oneCommented:
1) What is a good foundation for the site?  HTML5?

Maybe.  What is the site going to do? What do you mean by "foundation" ?

2) What is a good design environment to use that will create a site that renders well on multiple platforms.

What, specifically, are you asking for?  Language? IDE? Something else?

Is this a good place to start?  http://www.google.com/think/multiscreen/

Sort of.  That's a very high-level set of whitepapers that touch on concepts...less so on techniques.  All knowledge is worth having, so it might be a good place to start but it won't get you very far.
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Bob SchneiderCo-OwnerAuthor Commented:
Here is a little background that might help.  I currently use WebMatrix (environment) to create sql server-backed sites in classic asp with css, html4, and javascript.  Largely through help from this site I am gradually implementing JQuery/Ajax.

I am very comfortable in this environment but is it outdated if I want to do more dynamic things.  For instance, I eventually want to do some mobile app programming.  It just seems to me that this is a good time to get out of what is comfortable and try to do something a little more contemporary.

I know that is very general...just wondering what direction I might get from this site.
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Jason C. LevineNo oneCommented:
So with that background, your path-of-least-resistance to modernization would probably be through .NET and/or node.js.  HTML5 is more of a toolkit upgrade for you rather than a whole new direction...you will need to know it to build things but you don't NEED it to build things.
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Bob SchneiderCo-OwnerAuthor Commented:
Thanks.  I will hang on here for a bit to see if I get any more suggestions.
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