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registry cleanup options?

I have a win 7 desktop that has slowed down.  rather than do a nuke and pave, I am trying something else - I uninstalled most apps I can reinstall easily, then manually compared the files / folder from a new / clean install against this used install and deleted files that I know aren't needed.

I can go into the registry and see loads of entries for intuit, quickbooks, quicken, Silverlight, etc even though I uninstalled those and other apps.

I've run ccleaner and free registry cleaner.  They don't seem to get those.  Like loads of things like these:

[HKEY_CLASSES_ROOT\Installer\Assemblies\C:|Program Files (x86)|Microsoft Silverlight|5.1.20125.0|

I can manually delete each of these keys, but it's delete, confirm then search again for Silverlight.

Is there a way to automate that / better registry cleaner?
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Qlemo
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Most registry cleaners do more harm than good and it really doesn't speed things up.
stay a way from registry cleaners

what i would do is
-have a backup first
-do a factory restore of the pc, and reinstall your needed software + updates

or do a fresh install
Yes, I forgot to say that. There isn't a significant effect by removing left-over registry entries. You would have to remove say 10% of keys.
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if you want to learn how to use registry cleaners, by all means , go for it
but keep in mind  - on auto setting - you don't know what they delete

if you want to solve quickly your problem, backup + install is the solution
BeGentleWithMe-INeedHelp --
I fully agree with the advice not to use Registry Cleaners.  In any event, old keys in the Registry are rarely the reason for a slow down.

Running Disk Cleanup is one of the best ways of cleaning up old and unnecessary system and non-system files.
http://www.sevenforums.com/tutorials/818-disk-cleanup-open-use.html

The reduction in space used on your hard disk should speed things up.  I assume you have run antivirus and antimalware scans.
also - you can have lots of other causes :
corrupt OS :
-run a chkdsk
-run sfc  - or a repair
bad hardware : run diags
overheating : install speddfan

etc...
thanks for the points.
Did any of the options above prove of particular benefit?  Always good to get feedback...
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after trying most things here with no / minimal improvement, creating a new user profile dramatically solved the slowness.
then it seems my comment was the closest :  
also - you can have lots of other causes :
 corrupt OS :