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O365 and Outlook 2010 communication protocol.

Hi,

We use O365 and Outlook 2010.

Can someone let me know what communication protocol between them?  I know SMTP is not being used.

When we use Outlook 2010 and on-prem Exchange 2010, IMAP was used.  

Thanks.
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Kotteeswaran Rajendran
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Suliman Abu Kharroub
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Thanks, everyone.