RPC errors with IIS and Outlook Anywhere

I'm looking for some guidance.
One of our clients running SBS2008 developed an issue last week where outlook anywhere stopped working (still haven't worked out why)
OWA worked fine internally, but there was/is no access from outside of the network "Page not available"
After reading through numerous different posts, I disabled Outlook Anywhere, removed the RPC PRoxy feature, rebooted, re-added the RPC Proxy feature and then re-enabled Outlook Anywhere.
There is still no external access to OWA or outlook Anywhere to mobile devices.
I've run test-outlookwebservices and receive 2 errors

id 1013 - Error when contacting the RPC/HTTP service at https://"external domain"/rpc
                 The remote server returned an error : (500) Internal server Error.

In IIS manager, SBS Web Applications, RPC - If i attempt to browse the directory on port 443
I receive an IE page "SBS Web Applications/RPC"  500 Internal Server Error
There is a problem with the resource you are looking for, so it cannot be displayed. Detailed Error Information
Module IsapiModule
Notification ExecuteRequestHandler
Error Code 0x8007007f
Requested URL https://localhost:443/Rpc 
Physical Path C:\Windows\System32\RpcProxy
Logon Method Negotiate
Logon User HWLINCS\Administrator

I would be very grateful for any guidance as i'm not getting anywhere and the client has no external email access.
Thanks in advance
Who is Participating?
t2sConnect With a Mentor Author Commented:
Finally managed to trace the fault to the fact that a telephone engineer had changed settings on the clients router !
Simon Butler (Sembee)ConsultantCommented:
Did the RPC Proxy virtual directories go back in to the correct web site?
If you run the SBS BPA on the system, does that flag anything?
Have you run the fix my network wizard?

t2sAuthor Commented:
Thanks for the reply simon.
The RPC directories were originally in the SBS Web Applications folder, when I removed and reinstalled RPC they were placed in the Default Website folder.
I havent run the SBS BPA but the fix my network wizard didn't find anything.
I'm currently in the middle of removing Outlook Anywhere and RPC...again.

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t2sAuthor Commented:
Ok, managed to get the RPC directories in the SBS Web Applications website, however, I still have no external access to Outlook anywhere.
When I run test-outlookwebservices I receive

ID 1013 Error - When contacting https://"externalurl"/rpc Received the error The Server committed a protocol violation. Section=ResponseStatusLine.

t2sAuthor Commented:
I'm having an on going nightmare with this setup.
t2sAuthor Commented:
I traced the fault to the router having been reconfigured by a telephone engineer !
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