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Is the host mydomain.com running a real FTP server?
How are you going to that site? Using which application? A web browser?
Looks like a firewall issue where ports 21 and 20 are not open on the FTP server.
Create a reliable backup. Make sure you always have dependable copies of your data so you can restore your entire system or individual files.
425 occurs when the server cannot open a socket for data transfer, try ftp from command line, do you get a prompt from your FTP server?
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