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change bios settings

how to change bios settings on 50 computers by sending batch file and click on it
as example disable   usb
2 Solutions
The BIOS can't be accessed from within WIndows unless there's a specific application designed to do so available for your brand/model PC.

For example, Dell PCs can use the Dell Client Configuration Toolkit - CCTK:

What's the brand/model of the PCs you'll be updating?
Danny ChildIT ManagerCommented:
obviously, you can't just disable the USB.  You also need to set an Admin password for the BIOS, and also to then Lock it.  

If you're worried about data loss/illegal program installation, then a more thorough option is something like Lumension Device Control.
This lets you specify which users can have which devices (including DVD-RAM disks, etc).  You can allow access to specific models of device too - ie USB printers, scanners, etc.

You'll also need to block downloads/installs of EXE files, etc, and also access to remote file-sharing sites.  

You may also want attachment filtering on your internet connection to block programs coming in via email, and to log (at the very least) data going out.
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