Exchange 2013 incoming mail issue

Dear Experts,

We are facing intermittent issue on our Exchange 2013 CAS server, out of 10 emails 1 emails get struck in ironport and says the following error.

Message id to email_id delayed. Reason: 4.3.0 - Other mail system problem ('451', ['4.7.0 Temporary server error. Please try again later. PRX5 ])

Environment:
Single AD Site
Two DC Win2012r2
Two CAS on Win2012r2
Two MBX server on Win2012r2
Iron Port for internal mails
External mails are routed via CAS directly through internet.
Internal mails are routed via Ironport>>CAS>>MBX1 server.
internal domain : domain.local, external domain : domain.ca
Public Cert added to both CAS, NTP are fine and syncs Time on all servers properly.
MBX1 has all mailbox homed, MBX Server2 has copy of MBX1 Primary database.

Users complaining incoming mails are getting delayed but not all the mails are delayed, out of 10, one email gets delayed and throws errors above said.

Please any idea or solution would be appreciated.