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Windows Server 2008 R2 periodic performance issue

Last Modified: 2015-04-03
I have a production server that periodically has an issue that the entire server runs EXTREMELY slow.  Usually the symptom starts by users complaining that the Exchange server (version 2010) is running slow because they receive messages at their desktop in Outlook that it is trying to communicate with the exchange server.  The exchange server itself continues to work, but the entire server is running slow.  When I attempt to look at the server I am unable to.  What I mean is, if I try a remote desktop session it won't connect.  If I try to physically look at the server, I connect do anything at the console.  I can see the mouse pointer move, but that is all.  The server is running so slowly that I cannot login to the server at the console or even see the desktop.  It is usually just a black desktop with the white mouse pointer.

So what I can do is perform a remote shutdown command from another computer on the network.  Once the command is successful and the server reboots then all is good.  To help alleviate this I am performing server reboots 3 times a week, which I shouldn't need to do.  

So I am looking for some advice on how to determine what is causing this condition to occur so it can be rectified.
Note: the server is very new.  It is a Xeon E5-2609 2.4 GHz, 64GB RAM, Windows Server 2008 R2.  The server runs Exchange 2010 SP3 and is also the company file and print server for about 20 users.

Any help would be greatly appreciated.
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