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Exchange 2013 stops processing emails about every 1.5 to 2 days

Event 6005: SmtpReceiveProtocolLogs: Failed to flush logging requests fast enough (maximum requests of 50000); was forced to flush synchronously. This indicates high disk latency or issues with thread starvation and indicates a performance problem.

Along with A message with the Internal Message ID XXX was rejected by the remote server.  This message will be deferred and retried because it was marked for retry if rejected.  Other messages may also have encountered this error.

At first I thought it was a drives space issues but the last hang was with 10 gig free space and that is double of where it used to be.

If I go to the Cloud spam filter service and run a test email I get this: Unable to set DATA: 452-4.3.1 Insufficient system resources
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dpcsit
Asked:
dpcsit
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dpcsitAuthor Commented:
Found this is the System log:

The Microsoft Exchange Transport service terminated unexpectedly.  It has done this 1 time(s).  The following corrective action will be taken in 5000 milliseconds: Restart the service.
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dpcsitAuthor Commented:
Followed by:

The Service Control Manager tried to take a corrective action (Restart the service) after the unexpected termination of the Microsoft Exchange Transport service, but this action failed with the following error:
An instance of the service is already running.
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dpcsitAuthor Commented:
I believe that was on the reboot that allowed emails to start working again.
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Adam FarageEnterprise ArchCommented:
Sounds like back pressure to me, esp if you are rebooting to fix the issue. How is the system setup, mainly the storage subsystem? I would look at the latency there and maybe setup some perfmon counters, but the error says it all and you need to look at the performance at the disk subsystem.
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dpcsitAuthor Commented:
All attempts to move the mail queue fail exchange 2013 not only won't run but it won't allow me to move folders to clear disk space to allow it to run.

Of course the MS site tells me to replicate the security settings for the new folders but things like ALL APPLICATION PACKAGES are nowhere to be found in my domain.

First failure was at 4 gig free from 100 gig C drive, second failure was at 9 gig after freeing up space. I don't think it's a space issue. Waiting for the next failure we are down to 7 gig with no options to free up anymore space since exchange refuses to allow me to move anything to another drive.

database was already moved to E.
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dpcsitAuthor Commented:
Ok got the queue moved by copying the entire program files to E drive with permissions.

Then performed the move and it seems to be working.

However in the old queue there are old mail folders called messageing.old-xxxxx(numbers) and the old mail.que file has 4 meg space used up. I have verified that the mail.que file and the tm.chk files along with other files listed here:
https://technet.microsoft.com/en-us/library/bb125177%28v=exchg.150%29.aspx

After I copied the folders to get the permissions to match I deleted the files in the queue in the new location so that they would recreate when the server was stopped and started.

So can I delete the entire queue folder in the C driver now?
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dpcsitAuthor Commented:
Server ran for about a month and even though there are 20 gig of free space it stopped again, reboot has it working but still no answer to what is causing it to arbitrarily stop processing emails.
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