I have been encountering an odd issue where my Microsoft office applications do not want to run inside RDweb access (or through Remoteapps and Connections) when you first initially launch them. I get an error stating "Couldn't open this program or file, either there was a problem with Word 2013 or the file you are trying to open could not be accessed".
I get that error for any Office application that I try and run. Our other apps launch fine. If I have another app already launched, like Acrobat, then there is already a connection established on one of our RDSH servers and I can open the Office applications without any concerns.
Any suggestions would be great, thanks.