Excel Macro to delete specific characters

What is the extent of the data can you post a sample workbook ?
gowflow

Column A and Column B only, approximately 6000 lines.

try this code

Sub DelChar()
Dim WS As Worksheet
Dim cCell As Range
Dim sTemp As String

Set WS = ActiveSheet
For Each cCell In WS.UsedRange.SpecialCells(xlCellTypeConstants)
    sTemp = cCell.Value
    sTemp = Replace(sTemp, ",", "")
    sTemp = Replace(sTemp, """", "")
    cCell.Value = sTemp
Next cCell
End Sub

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gowflow

Thanks. For some reason this is affecting the data in Column A in a manner that it is not desired.
What if I only wanted to apply these commands to Column B only??