Adobe Reader sometimes has issues opening within Internet Explorer all version

Hi All Experts,
This is not a very important issue at all so I am not looking for an answer quickly. So sometimes I have users that are using either IE9, IE10, or IE11 and when they access a link that will open a PDF file, either the page that opens will be completely blank, or the other possibility is that the page will open with the wonderful message Website not found. I have tripled checked to make sure the Adobe Reader add on is enabled in IE and even when this happens I can open Adobe Reader directly. The only way I have found to fix this issue is to go to tools, Internet Options, and under Advanced and perform a reset. Reboot the PC have the user log back in, and then I re enable all the add-ons (even though the Adobe Reader add-on never gets disabled but Java and a couple of other add-ons need to be re-enabled). So after I do this all is working fine. There must be a root cause that this is happening but for the life of me I cannot figure out what it may be.
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JohnBusiness Consultant (Owner)Commented:
I do not have any Adobe add-ins enabled and PDF's open fine for me. That is because the integration is part of Adobe (in its preferences). The only add-ins I have enabled are the Java add-ins. All other add-ins are disabled.

Try also in Internet Options, Advanced to use Software Rendering instead of Hardware rendering. That often helps.

Make sure you are using the newest version of Adobe Reader (11.x) and make sure Adobe, Flash, Java, and Windows are all up to date. Recent patches out for everything.

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HarleyITGuyAuthor Commented:
So how are PDF Files opening in IE without the Adobe add-on? And I will try the change to Software Rendering when the issue crops up again.
JohnBusiness Consultant (Owner)Commented:
I have Adobe preference set to up in an IE window and it opens as you would expect in IE. Try it.
HarleyITGuyAuthor Commented:
I will try this and thank you
JohnBusiness Consultant (Owner)Commented:
@HarleyITGuy  - You are very welcome and I was happy to help. Post back if you encounter issues.
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