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1. restart the computer,<br />
2. remove &amp;&nbsp;re install office ,<br />
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1. restart the computer,
2. remove & re install office ,

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Can you define &quot;plenty&quot; of resources? I often see RDA servers with too little memory for the number of users.
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Can you define "plenty" of resources? I often see RDA servers with too little memory for the number of users.

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Again, &nbsp;the user can't save a blank SS. &nbsp; 8VCPUs &nbsp; 32GB 5 users
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Again,  the user can't save a blank SS.   8VCPUs   32GB 5 users

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this is often caused by old temp files that are confusing Excel.<br />
try clearing out the users' temp folders and see if it solves.
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this is often caused by old temp files that are confusing Excel.
try clearing out the users' temp folders and see if it solves.

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Already tried that and it didn't work.
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as it works for some users and not others, it's something relating to the users profile. Are you using roaming profiles? could you try a new profile to confirm if the profile is the issue?
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as it works for some users and not others, it's something relating to the users profile. Are you using roaming profiles? could you try a new profile to confirm if the profile is the issue?

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I'm trying to avoid creating a new profile. &nbsp;I know recreating will fix it but resetting all settings manually is a real PITA. I was looking for a fix other than that.
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I'm trying to avoid creating a new profile.  I know recreating will fix it but resetting all settings manually is a real PITA. I was looking for a fix other than that.

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<div class="content wysiwyg-content">
I have a couple users on a 2012R2 server that cannot run Excel. &nbsp;They can't even open a blank worksheet without getting the &quot;Not enough resources...&quot; error. &nbsp;They are a 2012R2 VM with plenty of resources.
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I have a couple users on a 2012R2 server that cannot run Excel.  They can't even open a blank worksheet without getting the "Not enough resources..." error.  They are a 2012R2 VM with plenty of resources.

Excel 2013 insufficient resources when first open and trying to save even a blank worksheet on 2012R2 Terminal server.

Microsoft Excel topics include formulas, formatting, VBA macros and user-defined functions, and everything else related to the spreadsheet user interface, including error messages.

Microsoft Excel

Windows Server 2012 is the server version of Windows 8 and the successor to Windows Server 2008 R2. Windows Server 2012 is the first version of Windows Server to have no support for Itanium-based computers since Windows NT 4.0. Windows Server 2012, now in its second release (Windows Server 2012 Release 2) includes Foundation, Essentials, Standard and Datacenter, and does not support IA-32 or IA-64 processors.