User mailbox becomes disconnected 554 5.2.1

On our Exchange 2010 Server I recently created a new user mailbox for a new employee. For some reason this new mailbox becomes disconnected. When it becomes disconnected email to the user bounces: #554-5.2.1 mailbox disabled 554 5.2.1 STOREDRV.Deliver.Exception:AccountDisabledException.MapiExceptionMailboxDisabled; Failed to process message due to a permanent exception with message Cannot open mailbox Exchange Administrative Group

Following this article temporarily solves the issue:

Oddly over this past weekend the mailbox became disconnected late on Friday, tested to not work at 10:00pm. Monday morning the mailbox is working again without any user intervention.

I am starting to go through the servers event logs but wanted to throw this out there incase someone has seen this and has a fix.

Thanks for your input.
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Simon Butler (Sembee)ConsultantCommented:
Move the mailbox to another database, see if that cleans it up.
Otherwise I would be looking at a domain replication issue.


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Will SzymkowskiSenior Solution ArchitectCommented:
I would enable admin audit logging on the database where the mailbox resides.

Also, do you have any backup schedules that run when this mailbox gets disconnected? Also check that you do not have any scripts or scheduled tasks running either.

CanOfWormsAuthor Commented:
Hi Simon,
Thanks for the input. I created a new Mailbox Database and moved that person into. I will keep you posted. I will also look into Replication issues. You are speaking of AD Replication correct? Not Exchange?
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CanOfWormsAuthor Commented:
Thanks Will. I attempted to enable Administrator Audit but am not sure how to specify the mailbox database. I will work on this more tomorrow. Thanks for the guidance!

"You must specify the cmdlets and parameters you want to audit, and you must also specify the destination audit logging mailbox before you enable administrator audit logging. For more information about how to configure administrator audit logging, see Configure Administrator Audit Logging."

I will check on the timing of this issue RE: backups and scheduled tasks.
Simon Butler (Sembee)ConsultantCommented:
Yes, I am referring to AD replication. Exchange queries the AD frequently for the information. If you have a problem with replication, for example a setting is being overwritten by another domain controller, then that could cause something like this - basically a confused Exchange server.

CanOfWormsAuthor Commented:
I believe it was a Domain Replication issue.
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