SQL Reporting services not sending mail

Hi Everyone from my sql server I'm unable to send this from SQL Server Reporting Services

Error message received on sql1 as follows:-

Failure sending mail: Mailbox unavailable. The server response was: 5.7.1 Unable to relay

How can I change settings on my Exchange 2010 server to get this to work.
Dirkie LaubscherNetwork adminAsked:
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