outlook keeps asking for pasword dozens of times a day

Try selecting other user
And enter your domain\username instead of your email address then your normal password tick the box to save the credentials

go to Control Panel\All Control Panel Items\Credential Manager or user account and manage your credentials on the left. once there check to see if your credentials to your local 2007 exchange is there, if it is check those settings to what it should be and if it is not create one. You say your email address it not yourname@domain.local and that this is the email that keeps asking for a password? If that is right then where is this email address going to get its emails from, what server if not the 2007 exchange server on-site?

Was any change made to the Exchange certificate?

Do you have more than one Exchange Server?  If so how do you control which one you connect too?  I have seen this type of situation when you get disconnect from one Exchange Server and re-connect to a different one.

Are you running any other software that may use Exchange on the backend?  Such as Lync or software based VIOP that might use Exchange for contact information?

domain\username  does not make a difference
exchange cert was renewed recently but this only affects 1 user the rest are fine
only 1 server with exchange and everything else on it

--> I thought when you logged into computer outlook should never ask for password

That is true, if the user-id you logged on to your computer with is the same user-id that is associated with your mail box and they both use the same authentication server.

So if you are using Active Directory, and your e-mail address is associated with your AD account and Exchange is using AD for authentication, then you should not get prompted for you user-id/password, normally.

However I just re-read your original post and saw:

--> I have tried using http and https

This implies you are using RPC over HTTP and it has been my experience when using RPC over HTTP you get promoted for you user-id/password every time you connect to the Exchange server.  I have heard that with the latest release of Outlook and Exchange this no longer occurs.

did you try this https://www.experts-exchange.com/questions/28635915/outlook-keeps-asking-for-pasword-dozens-of-times-a-day.html?anchorAnswerId=40664993#a40664993

link not working

that is simply a link to my earlier comment--re posting it here

[go to Control Panel\All Control Panel Items\Credential Manager or user account and manage your credentials on the left. once there check to see if your credentials to your local 2007 exchange is there, if it is check those settings to what it should be and if it is not create one. You say your email address it not yourname@domain.local and that this is the email that keeps asking for a password? If that is right then where is this email address going to get its emails from, what server if not the 2007 exchange server on-site?]

because this was the only correct answer