Why frequent account locked out - Event ID 4740

We have frequent account locks out that seem to be origination at user's workstations:

A user account was locked out.

Subject: Security ID: S-1-5-18

Account Name: DomainController$

Account Domain: NT_DOMAIN

Logon ID: 0x3e7

Account That Was Locked Out: Security ID: S-1-5-21-2030126595-979527223-1756834886-1337

Account Name: JohnS

Additional Information: Caller Computer Name: JohnS-PC

It affects only certain workstations on the domain, and we cannot pinpoint what is actually causing this behavior. We started noticing it last week - on the day we have added New routable UPN Suffix to all domain users. We have no idea if this is the cause or just a coincidence - we've seen this happening before, but it was usually caused by phones or persistent network connections. Any ideas how to tracked down a problem?
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singringAuthor Commented:
Long story short - we've found it was Outlook locking the accounts (we added UPN suffix to prepare to implement AD federation service).
Mohammed KhawajaManager - Infrastructure:  Information TechnologyCommented:
You sure it is not due to a mapped drive. Or something similar. Try this tool from Sourceforge:
singringAuthor Commented:
100% sure not a mapped drive or existing network connection. In couple of cases we had cleaned stored credentials on the affected workstation and it fixed problems. We have also notice d lots of kerberos pre-authentication failed errors (event 5771) and account was logged off (event 4634). We enabled "Do not require kerberos pre-authentication" on 2 accounts and it fixed a problem - not a single lockout.
Mohammed KhawajaManager - Infrastructure:  Information TechnologyCommented:
Stored credentials always becomes an issue after password changes as well as activesync devices which will require passwords to be changed.
singringAuthor Commented:
100% right, but in this case we've cleared all stored credentials and activesync is not an issue in this case (we do not host our exchange and just preparing to implement federation).
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