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Upgrade 2008R2 to BI2012 error message

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Last Modified: 2015-03-30
Hi,
  Thanks in advance for prompt answers to this question!
  On a virtual server running Windows 2008R2 with SQL Server 2012 Enterprise Edition and SQL Server 2008R2 already installed, received the following error at the start of the upgrade of 2008R2 to Business Intelligence version of SQL Server 2012.  Can 2008R2 be upgraded to BI edition 2012 with 2012 Enterprise already on the machine?
FYI:  using another SQL Server 2012 Enterprise Edition installation is unavailable at this point due to cost of licensing

ERROR MESSAGE:
Unable to open Windows Installer file 
'D:\x64\setup\sql_engine_core_inst_msi\sql_engine_core_inst.msi'.

Windows Installer error message: 
The system cannot open the device or file specified.


Click 'Retry' to retry the failed action, or click 'Cancel' to cancel this action and continue setup.
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