We have recently setup new servers with Windows 2012 with Citrix Xenapp 7.5 (previously we had Windows 2008 R2 with Xenapp 6). Most of the applications have been setup and running without any issues. I seem to have an issue with Internet. Specifically Internet Explorer (NOT the IE APP, but iexplorer.exe). I have trying to get to the bottom of this but can't seem to find anything that will point me in the right direction. When a user logs on for the first time, IE works fine. By the second day, it no longer works. When they launch IE they get a blank white screen and then after a minute or so it closes. I installed Firefox in the meantime, but for some integrated Sites, they need to use IE. I though I was getting somewhere when I tried the following. I deleted the Registry Key HKCU\Software\Microsoft\Internet Explorer and relaunched IE to create the key and it started working again. My thought was to compare the Regkeys when it fails with the keys when it works. The only problem is that now even after I delete the keys, it still will not load. This happens to different users randomly. Really wish someone had any idea to help me find the problem. UAC is disabled for all users. No errors in Event Viewer.