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SAS 6G vs 12G

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Last Modified: 2015-04-02
I'm planning to purchase a new server HP Proliant 380p Gen9. but deciding harddrives seems to require research.
Currently I have HP Proliant 380p Gen8 and using a 146GB 6G 1k rpm 2.5" SFF Dual-port SAS (Model# EH0146FARUB Part# 512547-S21). But when I look at compatible harddrive list of HP Proliant 380p Gen9, it has 6G and 12G drives. For example,

HP 300GB 12G SAS 15K rpm SFF (2.5-inch) SC Enterprise 3yr Warranty Hard Drive 759208-B21
HP 300GB 6G SAS 15K rpm SFF (2.5-inch) SC Enterprise 3yr Warranty Hard Drive 652611-B21

If I mix them, how it affects the server? For example, mixing 2x 6G drives for C drive and 4x12G drives for E drive?

And how much different in real speed of the drive?
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