application to handle 500 user per click

i wish to built an application which will have around 500 clicks at a time. I need suggestion what combination on language and database i should use in .net.
rnsrAsked:
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David Johnson, CD, MVPOwnerCommented:
are we talking 500 clicks / second or minute? what is the response time per click? how much returned data is generated per click? you have too many open variables that a reasonable answer cannot be provided. .net is language agnostic so the choice of language is not involved here.

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