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Imports Excel = Microsoft.Office.Interop.Excel
Public Class Form1
Private Sub Button1_Click(ByVal sender As System.Object, _ByVal e As System.EventArgs) Handles Button1.Click
Dim xlApp As Excel.Application
Dim xlWorkBook As Excel.Workbook
Dim xlWorkSheet As Excel.Worksheet
Dim range As Excel.Range
Dim rCnt As Integer
Dim cCnt As Integer
Dim Obj As Object
xlApp = New Excel.ApplicationClass
xlWorkBook = xlApp.Workbooks.Open("c:\vbexcel.xlsx")
xlWorkSheet = xlWorkBook.Worksheets("sheet1")
range = xlWorkSheet.UsedRange
For rCnt = 1 To range.Rows.Count
For cCnt = 1 To range.Columns.Count
Obj = CType(range.Cells(rCnt, cCnt), Excel.Range)
//Here, check if the Cell i.e Obj.value has x and do whatever you want.
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