exchange 2010 does not send emails for internal and external emails

I am running exchange 2010 and the server has been up and running for years.  I get no error messages in the application log and the configuration looks the same, nothing changed.  There were no changes made to the server.  

any ideas of what to check?  Eventhough I have exchange 2010 running for so long I don't always work on it and I am not expertly experienced in Exchange 2010.

Thanks
Bulls-EyeAsked:
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Will SzymkowskiSenior Solution ArchitectCommented:
451 4.4.0 Primary target IP address responded with 421 4.2.1 unable to connect attempted failover to alternate host but did not succeed

If you expand the entire Last Error column what IP is it trying to send to? Is this for Outbound email? This typically happens when you have a reverse IP issue with your ISP for your MX record or your IP has been blacklisted. I would also check this too.

Will.
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Will SzymkowskiSenior Solution ArchitectCommented:
First thing to look at is the Queue viewer. Check that and ensure that mail is not stuck.

Other thing to check is the Exchange Services and ensure that your databases are mounted.

Also check and make sure that your Receive/Send Connectors are not DISABLED.

Will.
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Chris MillardCommented:
Also, do you have any AV on your Exchange server that could be causing the mail to be blocked?
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tmoore1962Commented:
Do you use self signed Certificates?  I would check and make sure exchange certificates are valid.  That is where i'd start.  Self signed certificate probably expired.
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Bulls-EyeAuthor Commented:
I see some entries in my queues but they look like spam entries and they have 451 4.4.0 Primary target IP address responded with 421 4.2.1 unable to connect attempted failover to alternate host but did not succeed.  ...

then i noticed someone trying to send an email and it gave 451 4.4.0 Primary target IP address responded with 421 4.2.1 unable to connect attempted failover to alternate host but that did not succeed.  either there are no alternate hosts or delivery failed to alternate host.  

I do run symantec mail security for exchange and symantec endpoint protection.  I don't see anything off hand.
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Bulls-EyeAuthor Commented:
I will check the certificates.  thanks
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Bulls-EyeAuthor Commented:
the certificate states it is valid  to 11/12/2017
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Bulls-EyeAuthor Commented:
it started working!!! I don't know why?!
thanks for all your help.  I really need to get my server checked out.  where or who would be good to do exchange consulting work?
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Bulls-EyeAuthor Commented:
I definitely have reverse IP issues somehow.  I have been trying to fix that for a long time.
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