We have Exchange 2010 Server running Multirole for CAS,HT,MB. We have clients that are both local and remote. We are using Outlook 2010 for client applications. All of the clients that are on Same LAN work with no issues. We have other clients that are on our WAN that has a firewall at remote side. Originally the remote clients could not setup their Outlook client at all. Then we added passthroughs on firewall for TCP ports 443 and 135. At that point the outlook would autoconfigure but would not actually get any mail in the remote client mailboxes. The mailbox say it is disconnected all the time. I am sure this is a firewall issue but not sure what ports are gong to be needed so that the outlook clients can commuicate to the CAS/MB Exchange and get and send email. What ports do i have to have opened on firewall to allow remote clients to reach back?