Netscaler 10.1 will break in ESXI host 5.5 Update2


We have 3 ESXi hosts that have local storage installed. We purchased an HP ProLiant DL380 Gen9 and then discoverd that, that ProLiant Server will only work on VMware ESXi host 5.5 Update 2.

We have updated VCenter to 5.5 Update1 and things appears to be working just fine.  We are planning on updating the other 2 Vcenter servers to VMware Update 5.5 Update 2 soon.  The other 2 servers are currently at VMware version 5.1 Update 1.

We discovered today that Citrix Netscaler version 10.1 will not work on ESXi host version 5.5 update 2.  We were told that we must update Netscaler to a newer version.  Lets say 10.5.  My questions are the following:

1.  Is it true that netscaler 10.1 will not work on VMware 5.5 update 2.

2.  Will the fix be to update netscaler to a newer version?

3.  Will the newer version of netscaler not work with any version of Citrix XenApp?
        a.  We are currently using XenApp Server 6.0.
        b.  We are getting ready to update to Citrix XenApp 7.5.

Please reference:

Since we have had 2 pretty specific errors or surprises, I can't help but think what else may go wrong when we update the ESXi hosts this weekend.  

4.  Are there any known problems that VMware 5.5 Update 2 will not work with Exchange 2010 or anything windows related?

5.  Is it normal to have VMware ESXi host not work with some specific applications like Citrix or anything specific?

Please answer the above 5 questions.
PkafkasNetwork EngineerAsked:
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Andrew Hancock (VMware vExpert / EE MVE^2)VMware and Virtualization ConsultantCommented:
1. Where is your reference to this ? Patch levels of ESXi, should not affect the running VMs, and their hardware.

2. Please provide Citrix reference ?

3. Please provide Citrix reference ?

4.  Patch levels of ESXi, should not affect the running VMs, and their hardware.

5. Never heard of it.

Virtual Machine Guests run on VMware virtual hardware, this hardware is the same for all versions of ESXi 5.0, 5.1 and 5.5.
Brian CTXSupportCitrix ConsultantCommented:
The only known issue I'm aware of with Netscaler on ESX had to do with two specific ESX builds:  ESXi 5.1.0 2191751 and VMware ESXi 5.5 2143827

Work-around posted here:
Tony JohncockLead Technical ArchitectCommented:
There is a Citrix workaround for the Netscaler issues on VS 5.5 - I can only assume this is relevant to you. The permanent fix is indeed to update to a newer version of NS firmware:

In terms of compatibility there are matrices published by Citrix.

For NS 10.5:

For NS 10.1:

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PkafkasNetwork EngineerAuthor Commented:
Hello Andrew Hancock,  

We discovered this information from a Citrix Consultant, and he just saw the problem in teh field.  Tony1044 found some good articles verifying his statements.
Brian CTXSupportCitrix ConsultantCommented:
Are my posts invisible?  :P
PkafkasNetwork EngineerAuthor Commented:
Hello Brian CTXSupport,

Your posts are just as valuable thank you.

1.  I wanted to verify what the Citrix consultant told us is correct and we just do not try to address it on blind faith.
          a.  Both Brian CTXSupport and Tony1044 support that position.

2.  It appears that a newer version of netscaler will correct that connectivity problem.

3.  I am still not certain if NetScaler 10.5 build 55.8 will work with Citrix XenApp 7.5.
        a.  I do see reference that it will work with Xen App 6.5; but that is considered kind of old now.
        b.  Will NetScaler 10.5 build 55.8 work with Citrix XenApp 7.5?
        c.  Or must we upgrade to Citrix XenApp 6.5?

A Citrix article states that Citrix XenApp 7.5 came out in May of 2014:

Acording to Tony1044, there is an article that was updated in Updated: 2014-Aug-04 that states Citrix Xen App version 6.5 is the way to go:

Citrix XenApp 7.5 might be a happy work around unless Citrix Netscaler 10.5 will not work well with it.  You would think it would; but, I would hate to find out after the fact.  Are there any known problems with using NetScaler 10.5 build 55.8 with Citrix  XenApp 7.5?
Brian CTXSupportCitrix ConsultantCommented:
You can get around the issue with by changing the patch level of ESX.  The Netscaler will work on both older and newer builds of ESX as long as it's not either of the two that I mentioned.  From what I have personally seen of this specific issue, it will not matter what version of the NetScaler code you are running.

NetScaler 10.5 will work with XenApp 6.5 & 7.5.  So will NetScaler10.1.

I would just deploy 7.6 if you are going to upgrade, other you are just duplicating work when you eventually deploy it later.

There are some issue with the 10.5 code (bugs with LDAP specifically), but it has nothing to do with the XenApp version.
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