Routine PC and laptop maintenance/housekeeping programme

To avoid re-inventing the wheel, can anyone point me at suggested contents of a routine (quarterly/bi-annually...) programme of office and remote worker desktop PCs and laptops maintenance?
I'm thinking of things like:

Antivirus scanning
Other malware scanning
Disk Defragmenting
Exterior and interior cleaning

Anything else to implement?

Thanks in advance.
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GlingoSystem AdministratorCommented:

You can add to this list:

Check installed software to see if there is no toolbars or unwanted softwares to uninstall.
Clean the registry and temporary files (Ccleaner can do this).
Check which softwares are launching at startup.
Check user profile size (treesize can help with this).

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Kash2nd Line EngineerCommented:
AV Scanning a quick scan daily should harm
Routine weekly things we do
 -- clear temp files
 -- updates check
  -- disk defrag
  -- Drive space check on Workstations etc

hope this helps
Paul SauvéRetiredCommented:
I use Norton360 Premier which automates the following at regular intervals:
Virus scans
Disk optimization EDIT: including disk defragmentation
File cleanup
Diagnostic reports (manual start)
Backups (with my defined schedule)
David_J_GAuthor Commented:
Thanks all
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