NIC IP settings for Exchange servers

I need to know if Exchange servers require the “Register this connection’s addresses in DNS” box to be checked as long as DNS was manually updated with the server’s IP.
We never check this box for any of our other servers as we always manually update our DNS.

We recently experienced an issue where email was building up on mail queue to the cloud on our Hybrid server. The Last error = 451 4.4.0 DNS query failed. The error was: DNS query failed with error ErrorRetry.
We just started getting this issue in the last two weeks and the Register address in DNS box had not been checked since server was created several months ago.
John WaterAsked:
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Simon Butler (Sembee)ConsultantCommented:
You aren't running your servers correctly.
In an AD domain that setting should be enabled on all AD members - the fact that Exchange is installed has nothing to do with it.

The DNS error you have posted is very generic, so it impossible to know if that is the cause of the problem.
There is a known issue with Windows 2008 R2 and some second level domains (, which can cause DNS issues similar to what you have posted.

AmitIT ArchitectCommented:
For MAPI NIC yes, for other NIC's like replication or backup NIC, you can disable it.
Will SzymkowskiSenior Solution ArchitectCommented:
You can also check out the KB article as well specifically for this error you are receiving,

John WaterAuthor Commented:
I did some research and found exactly what I was looking for in this article

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John WaterAuthor Commented:
it was closest to what I needed.
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