Remove malware and adware from a MAC OS X 10.6.8

Hello Experts, I have a MAC that has viruses and adware.  I have ran Avast and Sophos Antivirus cleaners and the Avast found and removed some items.  However when I open Safari and go to a different page than the home page I start getting pop-ups and Avast show that I have a js:ScriptPE-Inf[Trj] infection.

The process is /system/library/privateFrameworks/WebKit2.framework/
The file is /Users/username/Library/Caches/com.capple.Safari/Cache.db-journal

Any thoughts on how to complete clean this system?
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Andy MIT Systems ManagerCommented:
Sounds like it may be something in the internet files cache, maybe a temporary file that's being accessed.. You could try a reset in Safari to see if that cleans it out:

    Open Safari
    Click on Safari in the menubar
    Click on Reset Safari
    Make sure that Remove All Website Data is checked
    Click on Reset

If you are using Safari 8 (OS X 10.10 Yosemite) please use the instructions below:

    Open Safari
    Click on Safari in the menubar
    Select Preferences
    Click the Privacy Tab
    Select Remove All Website Data...
    Click Remove Now

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Also, try this:

Open Safari
Open Preferences (command ,)
Click Extensions

Next, find the extension that might be doing this and remove it or just turn off all extensions.
tucktechAuthor Commented:
This worked, thanks!
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Mac OS X

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