Exchange 2010 mail returns from a outside domain

We have mail being returned from an Italian domain, but using gmail, it works fine. I've read where it can be our DNS problems, but not sure how a misconfigured DNS would affect a single outside domain.

Error.......#550 4.4.7 QUEUE.Expired; message expired ##

Also read......
SMTP Extended Error 4.4.7 equates to:

4.x.x = Persistent Transient Failure
x.4.x = Network and Routing Status
x.x.7 = Delivery time expired

This correlates with the message you have reported with this error.

The most common cause for this error is that your message was held for an extended period of time at an intermediate relay server because that server could not connect to the 'next' server the message was to be delivered to. Typically this will be either an ISP's relay server which could not deliver to an end-user server, or a corporate edge server which could not deliver to a final mailbox store server.

In your case, it sounds like your senders mail server (or their ISP's relay mail server) is unable to connect to your mail server to deliver the message to you. I've seen this before where the sending mail server is behind an improperly configured firewall - specifically one configured to drop packets to / from bogons. It's difficult to be 100% certain if this is your issue without also seeing the Received: headers from the NDR, but this is one fairly likely scenario. Ask your message sender to check their firewall logs at the time they are trying to send a message to you to verify this.

Really not sure where to look internally.
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HaroldNetwork EngineerAsked:
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HariomExchange ExpertsCommented:
First find the mx of outside domain then send e-mail to  outside domain using telnet from your server and check the results.

steps from your exchange server :-

nslookup
set q=mx
outsidedomain.com
you will get domain mx of outsidedomain.com

telnet to outsidedomain  mx server on 25 port (telnet outsidedomainmx 25)
try to send test e-mail and post the results.

Also following tool is available to test your server smtp

If you are facing issues where your outgoing Emails are consistently rejected by other servers or land up in Junk Email or SPAM folders of the recipient mail box, this test can help you in identifying the problems.

Testing Process

Send an Email to test@allaboutspam.com
That email will bounce with a URL in the bounce messge.
Either click on the URL or Copy/paste the URL in a browser.
You will see report on your Email Server.
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HaroldNetwork EngineerAuthor Commented:
I'll get this information, test and let you know the results.

Thanks
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HaroldNetwork EngineerAuthor Commented:
I don't have user access to test sending from since it is not our domain or mail server. We just keep getting bounced mail.

mx : mx.nitrex.it
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HaroldNetwork EngineerAuthor Commented:
this was resolved with these instructions, from another post of mine.

During the analysis, I'm assuming you never setup your TLS correctly. While this is a nice feature (data is encrypted between your mail server and the destination), I'd say, use it after you read up on it, and want to enable it (maybe start a new question later on EE).
For now, disabling it is the fastest option:
http://blogs.technet.com/b/get-exchangehelp/archive/2013/02/05/disable-opportunistic-tls-between-an-edge-server-and-a-hosted-service-such-as-exchange-online-protection.aspx
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Seth SimmonsSr. Systems AdministratorCommented:
This question has been classified as abandoned and is closed as part of the Cleanup Program. See the recommendation for more details.
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