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PC after PC starts having problems with two of our programs.

We have two programs, both of which are connected to a SQL server.
From one moment to another, the programs start to fail.

Program A(DOCX)  is about 15 min up to start up
When up and running it works fine
If program is shutdown and started up again it takes again about 15 min.

Program B (COMOS) stops working with the following Error message:
Eventviewlog: The program Comos.exe version stopped interacting with Windows and was closed. To see if more information about the problem is available, check the problem history in the Action Center control panel.

"Fix" that don't work:
If a New users connect to the "damaged" PC - the programs don't work
Clean PC with Barracuda Antimalware - no difference
Clean PC with  Ccleaner- no difference
Flash uninstalled - no difference
Moved hard drive to another PC - the problem moves with hard drive...
Reboot and update SQL Server - no difference
Deleted user profiles and log on again - no difference

Solutions that works:
If the user switches to another PC the programs are running again
If the PC are reinstalled, the programs are running again
If the user are added as Domain Admin, , the programs are running again.
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Adam Leinss
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Check the event log and system restore points.  Sounds like something like a windows update got pushed out.
did you try a system restore to a date it was ok?  seems the the easiest way out here
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1. We have checked the Event log - no clue there that gives any hint ..
2. System restore. Have tried that - no succes in that either.

Currently we are checking the SQL connection and we found that we have a problem with the ADO connection, OLEDB works, but ADO don't.

Anyway - any new will be posted...
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