<div>
I think you will need the cname autodiscover record to exist on all domains you are trying enable autodiscover from.<br />
Have you looked at the remote connectivity analyzer from MS?<br />
<br />
<a href="https://testconnectivity.microsoft.com/" rel="ugc nofollow">https://testconnectivity.microsoft.com/</a>
</div>


I think you will need the cname autodiscover record to exist on all domains you are trying enable autodiscover from.
Have you looked at the remote connectivity analyzer from MS?

https://testconnectivity.microsoft.com/ [https://testconnectivity.microsoft.com/]

<div>
I have implemented this successfully many times but all users typically had all suffixes represented in additional email address (not their primarySMTPaddress).<br />
<br />
You use SRV records in this scenario as mentioned here:<br />
<a href="https://technet.microsoft.com/en-us/magazine/dn249970.aspx" rel="ugc">https://technet.microsoft.com/en-us/magazine/dn249970.aspx</a><br />
<a href="https://filedb.experts-exchange.com/incoming/2015/07_w29/923121/2015-07-13-1405.png" target="_blank" title="2015-07-13-1405.png (223 KB)"><img alt="2015-07-13-1405.png" class="file-block lazyload" style="max-width: 655px;" data-src="https://filedb.experts-exchange.com/incoming/2015/07_w29/923121/2015-07-13-1405.png" /></a>
</div>


I have implemented this successfully many times but all users typically had all suffixes represented in additional email address (not their primarySMTPaddress).

You use SRV records in this scenario as mentioned here:
https://technet.microsoft.com/en-us/magazine/dn249970.aspx [https://technet.microsoft.com/en-us/magazine/dn249970.aspx]
2015-07-13-1405.pnghttps://filedb.experts-exchange.com/incoming/2015/07_w29/923121/2015-07-13-1405.png

2015-07-13-1405.png

<div>
<div class="content wysiwyg-content">
I have successfully used the 
<blockquote>
Set-HybridConfiguration –Domains &quot;contoso.com, fabrikam.com&quot;, &quot;autod:wingtiptoys.com&quot;
</blockquote>
 command to save a ton of money on certificates and ease the management of multiple autodiscover records.<br />
<br />
<b>My question is:</b><br />
<br />
Will autodiscover work in this scenario with the above HybridConfiguration...?<br />
<br />
<b>USER1@FABRIKAM.COM</b><br />
1. USER1: is a user with only one SMTP address of user1@fabrikam.com?<br />
2. USER1: the same user has no other email addresses.<br />
<br />
Will the user be able to utilize autodiscover without any other email addresses like <b>user1@wingtiptoys.com</b>?<br />
<br />
Thank you!<br />
K.B.
</div>
</div>


I have successfully used the Set-HybridConfiguration –Domains "contoso.com, fabrikam.com", "autod:wingtiptoys.com" command to save a ton of money on certificates and ease the management of multiple autodiscover records.

My question is:

Will autodiscover work in this scenario with the above HybridConfiguration...?

USER1@FABRIKAM.COM
1. USER1: is a user with only one SMTP address of user1@fabrikam.com?
2. USER1: the same user has no other email addresses.

Will the user be able to utilize autodiscover without any other email addresses like user1@wingtiptoys.com?

Thank you!
K.B.

Using SRV for autodiscover records  and AUTOD:  with the Set-HybridConfiguration   command (hybrid 365 environment)

Office 365 is a group of software plus services subscriptions that provides productivity software and related services to its subscribers. Office 365 allows the use of Microsoft Office apps on Windows and OS X, provides storage space on Microsoft's cloud storage service OneDrive, and grants 60 Skype minutes per month. Office 365 includes e-mail and social networking services through hosted versions of Exchange Server, Skype for Business Server, SharePoint and Office Online, integration with Yammer, as well as access to the Office software. All of Office 365's components can be managed and configured through an online portal; users can be added manually, imported from a CSV file, or Office 365 can be set up for single sign-on with a local Active Directory using Active Directory Federation Services.

Microsoft 365

Exchange is the server side of a collaborative application product that is part of the Microsoft Server infrastructure. Exchange's major features include email, calendaring, contacts and tasks, support for mobile and web-based access to information, and support for data storage.

Exchange

The Domain Name System (DNS) is a hierarchical, globally distributed system responsible for associating the name of a computer, service or other resource into an IP address for connecting to the Internet or a private network. Most prominently, it translates domain names to the numerical IP addresses needed for the purpose of computer services and devices worldwide.