sending email to a specific domain uses smtp server from old Outlook profile

Mail service has been migrated to office 365.  New Outlook profile created and working.

When user sends mail to a specific domain, Outlook sends it using smtp server from previous profile and the smtp server rejects the mail and returns NDR as the senders account has been disabled when old mail service was discontinued.

Where is Outlook getting the smtp information from the old profile settings?
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Scott GorcesterCTOCommented:
I would delete the users Outlook Profile and run Outlook and recreate using the wizard.

K BCommented:
Unless you migrated and currently have a hybrid coexistence server you have to create fresh outlook profiles from scratch. Anomalies will occur if you attempt to use your existing profiles.

Did you create brand-new profiles after you migrated?
mwoodringAuthor Commented:
Yes this was a fresh profile created for the Office 365 move.  The smtp server was not configured in the new profile however emailing to this specific domain continues to try to use the smtp settings from the previous profile.  Could it be something in the registry?
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K BCommented:
The best test would be to use OWA.

Let me know if the results are the same.

Can you also reply with the full text of the NDR redacted?
K BCommented:
Also run from elevated command prompt


Did you use simply your email address and password to set up the outlook profile (autodiscover)?

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mwoodringAuthor Commented:
The profile was set up using autodiscover.  I will try the flushdns command tomorrow and test sending using owa.

Thanks for the suggestions.
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