Here's the issue. I have 1 DC running Server 2012 R2 Standard and 1 RDS Server running 2012 R2 Standard. Office 2010 Professional Plus is installed on the RDS Server. Up until today, workers were able to remote into the RDS server thru RDC and use Office 2010. We use folder redirection so that they have access to all of their folders/files. No issues there. However, when they now try to open a word doc it starts the Windows Installer service, which then tries to configure Microsoft Office Professional Plus 2010. It then errors out with the following: "Error 1317. Setup cannot create the folder C:\Program Files\Microsoft Office\Office 14. Verify that the path exists in your system and that you have sufficient permissions to update it." I tried logging in as Administrator as well as a regular user, and get the same message. No updates were installed on the RDS server. The DC server did have some updates installed over night. But I can't see how that would affect the Microsoft Office software. All other programs (Adobe, LexisNexis, etc..) work fine. It's just the Office applications. I tried to do a "repair", but that errors out too with the same error message. It won't even let me uninstall it. (same error message) Any help would be Greatly appreciated!