I had an issue with my profile on a 2008 server. I had further issues with my profile and had to re-create it. I went to the applet to delete the profile but the delete button was greyed out. I removed the registry key HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows NT\CurrentVersion\ProfileList and deleted my profile. This then removed it from the applet.. when I try login I now get an error the user profile service failed the logon. I am also unable to deleted my profile from c:\users.
I am presuming the registry has another setting referencing my old profile that I need to remove so my profile gets re-created. Thanks.