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There are several issues that may be relevant to your question. &nbsp;Please say which ones apply. <br />
<br />
* duplication the IIS configuration<br />
* duplication of application code<br />
* duplication of data<br />
* Working in an active/active or active/passive mode<br />
* Internal site vs External site
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There are several issues that may be relevant to your question.  Please say which ones apply.

* duplication the IIS configuration
* duplication of application code
* duplication of data
* Working in an active/active or active/passive mode
* Internal site vs External site

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I need to setup IIS failover to a remote data center in case of an emergency. <br />
<br />
We will be connected to the remote data center with a site to site connection. <br />
<br />
What's the best way to set this up? Failover cluster? NLB (probably not) or something like simplefailover.com?
</div>
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I need to setup IIS failover to a remote data center in case of an emergency. 

We will be connected to the remote data center with a site to site connection. 

What's the best way to set this up? Failover cluster? NLB (probably not) or something like simplefailover.com?

Best way to setup IIS failover to remote datacenter?

Cloud computing, also known as on-demand computing, is a kind of Internet-based computing where shared resources and information are provided to computers and other devices. It is a model for enabling ubiquitous, on-demand access to a shared pool of configurable computing resources. Cloud computing and storage solutions provide users and enterprises with various capabilities to store and process their data in third-party data centers, relying on sharing of resources to achieve coherence and economies of scale.

Cloud Computing

IIS is Internet Information Services, the web server included with Windows Server operating systems. All current versions are built on a modular architecture; modules can be added or removed individually so that those required for specific functionality are installed. The full installation of IIS includes HTTP, security, content, compression, caching, logging and diagnostics.

Microsoft IIS Web Server

Microsoft server applications are those applications developed specifically, but not necessarily exclusively, on the Windows Server platform. In addition to well-known products like SQL Server, Exchange, Internet Information Services (IIS), Microsoft Dynamics, Forefront, Lync and Sharepoint, they include applications like Skype, BizTalk, Hyper-V, Groove and Commerce Server. Server applications are managed with the Microsoft System Center.

Microsoft Server Apps

The Windows operating systems have distinct methodologies for designing and implementing networks, and have specific systems to accomplish various networking processes, such as Exchange for email, Sharepoint for shared files and programs, and IIS for delivery of web pages. Microsoft also produces server technologies for networked database use, security and virtualization.

Windows Networking

Windows Server 2008 and Windows Server 2008 R2, based on the Microsoft Vista codebase, is the last 32-bit server operating system released by Microsoft. It has a number of versions, including including Foundation, Standard, Enterprise, Datacenter, Web, HPC Server, Itanium and Storage; new features included server core installation and Hyper-V.