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Exchange 2010 Performance issue

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Last Modified: 2016-06-10
When someone sends an email out to everyone in our firm via a distribution list of about 225 people, we notice the outlook bubble Outlook trying to retrieve data from the exchange server.... pauses for about 5 seconds and goes back to normal.  This happens most days but not every day.    trying to put the pieces together. Any help would be appreciated.

Exchange 2010 with two mailbox servers running on one mailbox server \other is passive node, with two cas servers.
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