Exchange 2010 Performance issue

When someone sends an email out to everyone in our firm via a distribution list of about 225 people, we notice the outlook bubble Outlook trying to retrieve data from the exchange server.... pauses for about 5 seconds and goes back to normal.  This happens most days but not every day.    trying to put the pieces together. Any help would be appreciated.

Exchange 2010 with two mailbox servers running on one mailbox server \other is passive node, with two cas servers.
MorrisonCohenAsked:
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Will SzymkowskiSenior Solution ArchitectCommented:
Are your outlook clients using cached Exchange mode or online mode? Also does this happen when the sender has attachments or not? When this happens check the performance of The Exchange server holding the HUB Transport role.

Will.
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MorrisonCohenAuthor Commented:
We are in online mode - checked the hub sever and didn't see any problems?
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Will SzymkowskiSenior Solution ArchitectCommented:
Does this happen all the time? Does the user send it out with attachments? Have you checked your resources on the mailbox server? Does this happen to all users?

Online mode uses Exchange server resources so if you have EVERYONE using online mode it is using constant NETWORK and Exchange Resources which can give you this message that you are receiving. I bet if you switched to cached mode on someone mailbox this would not happen as cached mode uses local machine resources for searching etc, and periodically makes connections to the Exchange server.

Will.
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MorrisonCohenAuthor Commented:
Happens most of the time but not all the time - no attachments just a simple test email will cause it.  Cache mode is not an option as it conflicts with applications we have.    I checked all servers and so not see anything server side.   That's why I am looking at white space but I guess that has nothing to do with it.
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MorrisonCohenAuthor Commented:
Any other solutions?
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Will SzymkowskiSenior Solution ArchitectCommented:
That's why I am looking at white space but I guess that has nothing to do with it.
You are correct.

Have you checked your Exchange Resources? The biggest performance hit for Exchange is Disk IOPS (I/O).

Another test would be stop the Exchange Search assistant and see if it you experience the same issue. Using Outlook with Online mode is hard on the indexing/searching when mailboxes have a lot of inidividual emails.

However, are you able to test with one user in cached mode to see if it actually corrects it? If it does then you know it is resources to the Exchange server that is lacking.

Will.
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