We use Cisco AnyConnect for our VPN into our office. A few users print to LAN printers while connected since we don't allow local printing while connected to the VPN. They had been printing through a Windows 2003 print server without issue. But now when the print through the new Windows Server 2012R2 print server print response have slowed greatly. While in any application, lets say MS Word, and they print now it will sit in the application with the print dialog box open for several minutes before eventually responding. It has been known to hang the application too.
I do not believe this is a VPN issue - unless there is some new setting within the ASA that needs to be changed to accommodate the new 2012R2 print server. It is not the content nor is it their internet connection - both are constants prior to and after the print server migration. To me it sounded like a print server issue but I'm not quite sure where to start looking.