I'm having a similar issue to the case 28047361 but my Default hive isn't abnormally large. It's only 1.2MB. When a remote user logs in events 1515, 1511 and 1500 are generated on the TS. Event 1500 reports "The system cannot find the file specified.".
We're running folder redirection with group policy for the AppData, Desktop and My Documents for each AD user. The default of "local path" is selected for both the AD profile and the RDS profile. Rebooting doesnt seem to help with the logins. We have about 25 remote users and yesterday only 4 had an issue and this morning about 1/2 are affected.
Is there a problem with the registry default profiles or something else at play here?