New Web development for large scale application for existing Windows product.

What is the latest technology for web development like patient portal (Health care product).
Is single page application preferable? Which one do you prefer.  It should be salable and better performance.
Our Target Technology: .Net Framework  >= 4.5 , HTML5, CSS3, Javascript, Dapper, Angular, Web Api, MSSql Server.
Our Target Platform: Windows, Mac.
Our Target Devices :  desktop, Tablet, mobile

Presentation Layer
Which css framework do you prefer for large scale application. Like Bootstrap, Foundation, Materiel Design,
Which Third parity controls do you prefer for UI development. like infragitics, Telerik, etc (especially grid control)
Which javascript framework is good for large scale framework. like Angularjs, Ember, Winjs, Extjs, or javascript native code, etc..

Service Layer
Which identity provider do you prefer for small and large scale application.
Which one do you prefer for rest service?  WCF / Web Api.
How to secure Rest service other than SSL. (Message level Security)

Data Access Layer
Do you prefer any ORM for Data access layer (MS Sql server - Express edition  ) like Dapper, Entity Framework, Nhibernate, or pure Hand code ?