Defrag or not to Defrag...that is the question

Hello,
I have a bit of a problem.  I've got an Exchange 2010 sp2 rollup 8 server that everybody seemed to have forgotten about for a couple years and the performance is awful.  The worst part is that it really only hosts one mailbox (aside from admin and discovery/search) that people use as their CRM and share the calendar with a bunch of complicated tasks and appointments.  The existing mailbox is now 18GB in size and the database has mutated into this 109GB disaster that has about 80GB of whitespace in it.  The server itself is Server 2008R2 on an ESXi 5.0 host.  The host is using NFS shares coming off a NetApp.  The configuration is as follows:
Host:  Esxi5
Datastores:  Storage1(Local)--84GB free/272GB
VMWare1(NFS)--148GB free/970GB
VMWare2(NFS)--121GB free/690GB
VM:  Ex01
HDD1(C:): 55GB vmdk in VMWare2.  22GB free
HDD2(D:):  350GB vmdk in VMWare1.  241GBfree  and houses the exchange DB.
HDD3(E:):   140GB vmdk in VMWare1.  138GBfree and houses the exchange logs
HDD4:  32GB vmdk in VMWare1. Page file
HDD5:  200GB vmdk in VMware1.  50GB free and has some old databases in there that are not mounted.
All of the vmdk files are in an EX01.domain.com folder in their respective datastore.  The vm's actual vmx file and working location is in a different EX01_1 folder within Vmware1.  VMware1 not only has VMDK1,2,3, and 4 in it but it also has a -000003.vmdk for each drive that is a snapshot that hasn't been modified in over a week.  Problem 1.  The 0000001 and 0000002 snapshots are gone now and vsphere says they need consolidation but "Consolidate" is grayed out and not an option.  Somebody said, at one time, they tried to consolidate the disks and the vm locked up and said the datastore was full and nothing would boot up anymore so they deleted them and only kept the 000003 vmdks because they had the most recent modified date.  
Problem 2:  I try moving the 18GB mailbox to a new database on drive D: so I can remove the fragmented DB and I get:
Error: MapiExceptionNotFound: Unable to synchronize manifest. (hr=0x8004010f, ec=-2147221233)
Diagnostic context:
    Lid: 55847   EMSMDBPOOL.EcPoolSessionDoRpc called [length=239]
    Lid: 43559   EMSMDBPOOL.EcPoolSessionDoRpc returned [ec=0x0][length=719][latency=546]
    Lid: 23226   --- ROP Parse Start ---
    Lid: 27962   ROP: ropIncrCfg [112]
    Lid: 27962   ROP: ropUpldStStrmBegin [117]
    Lid: 27962   ROP: ropUpldStStrmEnd [119]
    Lid: 27962   ROP: ropUpldStStrmBegin [117]
    Lid: 27962   ROP: ropUpldStStrmEnd [119]
    Lid: 27962   ROP: ropUpldStStrmBegin [117]
    Lid: 27962   ROP: ropUpldStStrmEnd [119]
    Lid: 27962   ROP: ropUpldStStrmBegin [117]
    Lid: 27962   ROP: ropUpldStStrmEnd [119]
    Lid: 27962   ROP: ropFXSrcGetBufferEx [156]
    Lid: 17082   ROP Error: 0x8004010F
    Lid: 23137  
    Lid: 21921   StoreEc: 0x8004010F
    Lid: 27962   ROP: ropExtendedError [250]
    Lid: 1494    ---- Remote Context Beg ----
    Lid: 1238    Remote Context Overflow
    Lid: 21970   StoreEc: 0x8004010F PropTag: 0x668F0040
    Lid: 21970   StoreEc: 0x8004010F PropTag: 0x668F0040
    Lid: 21970   StoreEc: 0x8004010F PropTag: 0x668F0040
    Lid: 21970   StoreEc: 0x8004010F PropTag: 0x668F0040
    Lid: 21970   StoreEc: 0x8004010F PropTag: 0x668F0040
    Lid: 21970   StoreEc: 0x8004010F PropTag: 0x668F0040
    Lid: 21970   StoreEc: 0x8004010F PropTag: 0x668F0040
    Lid: 21970   StoreEc: 0x8004010F PropTag: 0x668F0040
    Lid: 21970   StoreEc: 0x8004010F PropTag: 0x668F0040
    Lid: 21970   StoreEc: 0x8004010F PropTag: 0x668F0040
    Lid: 46077   dwParam: 0xA52224
    Lid: 46121   StoreEc: 0x8004010F
    Lid: 22864  
    Lid: 3742    StoreEc: 0x8004010F
    Lid: 23296  
    Lid: 2526    StoreEc: 0x8004010F
    Lid: 20912  
    Lid: 24504   StoreEc: 0x8004010F
    Lid: 24148   StoreEc: 0x8004010F
    Lid: 23796  
    Lid: 2478    StoreEc: 0x8004010F
    Lid: 1750    ---- Remote Context End ----
    Lid: 26849  
    Lid: 21817   ROP Failure: 0x8004010F
    Lid: 32758  
    Lid: 16586   StoreEc: 0x8004010F
    Lid: 22518  
    Lid: 28874   StoreEc: 0x8004010F
    Lid: 29516  
    Lid: 31820   StoreEc: 0x8004010F

Can anybody help out?

Thanks!