The failure is a rather uninformative "550 Blocked" response from smtp-in.xxx.xx

Hello Experts,

Some users in another domain tried to email and they are getting a reply back The failure is a rather uninformative "550 Blocked" response from smtp-in.xxx.xx . I have the admin console to our exchange 2010 and would like to know if there is any thing I can do check why users in that domain can not email us.

Thanks,
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Habib ZakariaNetwork Solutions ArchitectAsked:
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Wayne88Commented:
If blocked then it sounded as if your antispam filter is blocking the sender from sending to your email server.  The reasons may vary.

SMTP 550 Blocked - Why is my email blocked with an error message?

I would start with your anti-spam filter to see what policies were set to detect an email as spam.  If you can, turn one off at a time to see if the email can come through.  Once it does then start tightening it again and reevaluate your anti-spam policy to see if you can make some exceptions.  Also, if the other domain is trusted then you may want to enter the other domain on the whitelist.  Whitelist by domain name and IP address.
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Habib ZakariaNetwork Solutions ArchitectAuthor Commented:
Yes you are right but do you know if the anti-spam filter is part of exchange or outside the exchange server.
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Habib ZakariaNetwork Solutions ArchitectAuthor Commented:
This is  outside the exchange.
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Wayne88Commented:
Hi, it really depends on your install.  For example, we have a separate anti-spam appliance and yes Exchange also have a built-in one.  I would make the exception for the other domain in Exchange first to see if that solve the problem.  If yes then that may be all you need to do.  If it's the external one then you will have to make the exceptions there and test to see if you're getting much spam coming through.   If you are then tweak accordingly.
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David Johnson, CD, MVPOwnerCommented:
where does your mx point to anti-spam can be either or local /remote
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Wayne88Commented:
In fact, if you have an external anti-spam filtration you may want to turn off some of these Exchange anti-spam features (2010 example) or at least have them off for testing purposes: Managing Anti-Spam and Antivirus Features

I don't see a point of having two and I don't think the built-in anti-spam is better than Sonicwall/Cisco ASA/Barracuda, etc.
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