IE gets pop-up

Somebody gave me this laptop to look at. It has Windows 7. They said it can't connect wirelessly. My first thought was, can it still connect through a cable. So when I took i home I plugged a NIC cable to it. It can get wired Internet. But every time I open IE, I get a pop-up saying:

"The C:\Windows\ System32\ config\ systemprofile\ AppData\ Lo...\ FCSB000063445folder does not exist. The file may have been moved or deleted."

Then it asks me if I want to create it (yes or no). Regardless of which option I choose, I have to choose that option twice to make that pop-up disappear.
     Why do I get that pop-up?
     I don't know what version of IE this has because when I click "Tools," there is no "About Internet Explorer" option for me to click on. Isn't that strange?
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JohnBusiness Consultant (Owner)Commented:
Download, set up (save) and run Process Explorer from Microsoft (Systinternals). Look in the left side tree under Explorer and see if there are any strange (alphanumeric) processes. If so kill the processes, do not restart and then run Malwarebytes to get rid of the malware.

If no such processes, restart in Safe Mode and run Malwarebytes.

Once done, remove add-ins in Internet Explorer.

Then restart and see if you have made progress.
David Johnson, CD, MVPOwnerCommented:
have you tried running "iexplore.exe -extoff" ? and finding the bad addon a scan with malware bytes would also be  in order
"I don't know what version of IE this has because when I click "Tools," there is no "About Internet Explorer" option for me to click on. Isn't that strange? "
No, you should click "Help".

Or click Start|right click "Computer"|click "Properties".

Are you running "Shop to Win"?
If so it is a Trojan and you should run both antimalware (as suggested) and antivirus scans.
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john8217Author Commented:
I hope I'm not changing the original topic of this post, but, there's a new development. I ran Windows Defender Offline. It found some things and I followed the recommended action. But then, as a result, I couldn't log into any of the 3 accounts anymore (they're all admin accounts). It kept saying "The User Profile Service service failed the logon. User profile cannot be loaded."
     So I then booted to Safe Mode and logged into one of the accounts. I did some research. It said to go to a specific place in the registry  to find a .bak file. Problem is, it wasn't there. So I did a system restore and that restored everything (and also put me back where i started before I ran the scan).
     I created a brand new admin account. It's my intention to delete the other 3 accounts. Will this help to delete most of the malware?
     But here is the new problem: for all 3 accounts (and even the new 4th account!!!) when I logon, I get a message from the taskbar saying "Your user profile was not loaded correctly. You have been logged on with the default profile for the system. Please see the event log for details or contact your administrator" What should I do about this?
David Johnson, CD, MVPOwnerCommented:
restore your system using system restore.
did you even attempt the iexplore -extoff and run without addons and then go into the addons and check (they will all be disabled).

I'm almost thinking doing an over install of the o/s (upgrade from win7 to win7 may help resolve of the system needs to be nuked and then a total reinstall is needed.

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JohnBusiness Consultant (Owner)Commented:
Deleting accounts will not normally delete malware. The system appears to have so many issues that you will be better to back up the computer and reinstall Windows fresh.

If the machine will do it, do a bare bones install of Windows 7 SP1 and upgrade to Windows 10. In the Windows 10 setup options do not keep anything.
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