Web browser pop up keeps coming back

I have a client that keeps getting a popup. This is on his home and work PC's. I have run malwarbytes, adwcleaner, rkill, tdsskiller, combofix, microsoft security essentials and have vipre anti virus installed.

Combo fixed seemed to fix it for a day but it was back by end of next day. He is pretty good at getting viruses... So it is hard to tell if he is just re infecting himself visiting a bad website or if i am not cleaning it off. Attached is a picture of the pop up.

I have reset browsers and cleared temp folders also.

merrill.jpeg
BrendleAsked:
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JohnBusiness Consultant (Owner)Commented:
Download, install and run Process Explorer from Microsoft (Sys Internals). Look under the Explorer tree (left side) for strange (alphanumeric) processes. If these exist, kill them but do not restart.

Run Malwarebytes again to get rid of viruses and malware.  Now restart.

If you still see the popups, restart in Safe Mode, no networking and run Malwarebytes in Safe Mode. Remove malware that way.

See if either approach above works.
Thomas Zucker-ScharffSolution GuideCommented:
What John said,  but chameleon by malwarebytes.org does the same thing.  Download chameleon
Extract
From the chameleon directory run the svchosts file
That will kill any known rogue processes
Update mbam
Run a MBAM scan

I also recommend using SPYBHORemover and SPYDLLREMOVER from securityxploded.com.

If this continues to come back,  it can't hurt to ruin several rootkit checkers (I recommend at least 3).

http://www.experts-exchange.com/articles/2245/Anti-rootkit-software.html

https://www.malwarebytes.org/chameleon/

http://securityxploded.com/spydllremover.php

http://securityxploded.com/bhoremover.php

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