Can I run IIS sites on different drives ?

I am running windows IIS7. I have my default website pointed at M://Web/

Then all websites are under that folder. One for each site.

Can I create a folder under C://Web\QFEBridgeTest  and run one website at that location ?

If so .. how ?
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yes, adjust the document root location.
i.e. when adding a site specify the location explicitly rather than relative.

do you use appcmd or the iis admin tool interface.
the default is c:\inetpub\wwwroot

see if the link explains it better,

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Windows Server 2008

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